Since I moved to Windows 10 I'm getting random freezes for a second or less when playing games with Mantle activated. On Windows 7 I didn't experience this problem previously. This happened to me with Battlefield 4, Battlefield Hardline and Sniper Elite III. After I switched to DirectX this kind of random freezing went away.
AMD FX-9590, 16GB RAM, R 290 4GB, W10 and latest AMD Beta drivers.