I have a Radeon HD 5450 running 2 monitors. My VGA feed is working fine and the screen is clear. I have tired both HDMI and DVI cable for the second monitor. Both cables result in low quality image.
Both monitors are viewsonic 32" I have them on the recommended display resolution. I have even switched connections and both monitors display correctly on VGA, but poorly on either HDMI or DVI.
This was not an issue prior to Windows 10.
I have updated to the latest driver for the 5450.