I'm currently running 2 R9 290X (Sapphire) reference cards.
They are connected to 3 ASUS PB278Q monitors.
Currently running Windows 10, and the 15.6 Beta drivers.
If I perform a clean install of anything newer I have severe issues (artifacting, green lines, etc) after a short while.
Upon restart it clears and comes back again shortly.
When going back to the 15.6 Beta drivers, it works just fine without these issues.
Asus P9X79 MB
16 GB Ram GSKILL 2400
2 x R9 290X Sapphire reference models
PSU: Corsair AX 1200i