I have about 55% of my ISRs coming from the atikmdag.sys process.
This causes my mouse to jump due to the volume of interrupts.
I have two R9-390 Nitro in Crossfire on a Gigabyte Z170XP-SLI Mainboard with Windows 10.
Two monitors are running, Main is HDMI. Second is DVI.
Mouse lag and jumping is far worse on the DVI monitor.