I used to use CodeAnalyst. Decided to give CodeXL a go. After installation Visual Studio 2010 SP1 was sluggish, often taking seconds to respond to keypresses. Every time you closed VS it would crash and restart. I never even got around to trying the profiler. I uninstalled CodeXL and VS started working perfectly again. The plugins I run are
Project Line Counter
Visual Assist X
Productivity Power Tools
The only thing I can think of that is unusual about how I use VS is that I have 8 instances running most of the time.