have you used any performance analysis tools?
Can you be a little more specific about what you are trying to do? The GPUPerfAPI library is provided so that you can integrate performance counter collection into your DirectX/OpenGL/OpenCL application. There are also tools provided by AMD to allow you to profile and debug your graphics and compute applications. CodeXL is available as both a standalone application as well as a Visual Studio plugin. GPU PerfStudio is available as a standalone application.