No, According to Asus Prime CPU SUPPORT LIST it doesn't list any 1st generation processors as being compatible: https://www.asus.com/Motherboards-Components/Motherboards/PRIME/PRIME-B550M-A/HelpDesk_CPU/
You can try and see if it boots into BIOS to be able to change the version. But if it doesn't boot up then you will know why.
