Safe Mode boots Windows into a minimal environment so that there are not a lot of apps and drivers being loaded into memory.
If you are using a keyboard and mouse that require apps or drivers to operate, (such as wireless keyboard/mouse) or through the front panel connected via the chipset, they likely won't work. You will need to connect a wired keyboard/mouse direct to the motherboard I/O panel.
If you just want to avoid booting into Safe Mode at this point, continue pressing F8 as the PC boots to get into the Windows boot menu where you should be able to choose to boot normally.
Ryzen R7 5700X | B550 Gaming X | 2x16GB G.Skill 3600 | Radeon RX 7900XT
Ryzen R7 5700G | B550 Gaming X | 2x8GB G.Skill 4000 | Radeon Vega 8 IGP
Ryzen R5 5600 | B550 Gaming Edge | 4x8GB G.Skill 3600 | Radeon RX 6800XT