i'm using 5700XT in Witcher 3. Had huge problems with blackscreens ingame. Found a solution for my case.
I played the game in maxed out graphics settings. Had the idea to turn down to minimum all graphics settings and then i had no blackscreens anymore. Can 100 % reproduce it ingame cos i have a save game file. On this place the game crash every time on maxed out.
Currently i figured out it is the shadow quality which cause my blackscreens. More tests needed.