Both GPU cards are the same Model and both support Crossfire so it should work if the Motherboard supports MultiGPU or Crossfire on it.
List of AMD Crossfire Supported GPU Cards: List of All AMD CrossFire Graphics Cards for PC
List of AMD Graphics Cards having CrossFire Support
Here is the list of all desktop graphics cards from AMD that supports CrossFire technology.
- Radeon RX Vega 64
- Radeon RX Vega 56
- Radeon RX 590
- Radeon RX 580
- Radeon RX 570
- Radeon RX 560
- Radeon RX 480
- Radeon RX 470
- Radeon RX 460
- Radeon R9 295X2
- Radeon R9 290
- Radeon R9 280X
- Radeon R9 280
- Radeon R9 270X
- Radeon R9 270
- Radeon R7 265
- Radeon R7 260X
- Radeon R7 260
- Radeon R7 250X
- Radeon R7 250
- Radeon R7 240
- Radeon HD 7970
- Radeon HD 7950
- Radeon HD 7870
- Radeon HD 7850
- Radeon HD 7770
- Radeon HD 7750
- Radeon HD 6990
- Radeon HD 6970
- Radeon HD 6950
- Radeon HD 6870
- Radeon HD 6850
- Radeon HD 6790
- Radeon HD 6770
- Radeon HD 6750
- Radeon HD 5970
- Radeon HD 5870
- Radeon HD 5850
- Radeon HD 5830
- Radeon HD 5770
- Radeon HD 5750
- Radeon HD 4870 X2
- Radeon HD 4850 X2
- Radeon HD 4890
- Radeon HD 4870
- Radeon HD 4850
- Radeon HD 4830
- Radeon HD 4770
- Radeon HD 4670
- Radeon HD 4650
- Radeon HD 4550
- Radeon HD 4350
- Radeon HD 3870 X2
- Radeon HD 3870
- Radeon HD 3850 X2
- Radeon HD 3850
- Radeon HD 3650
- Radeon HD 3470
- Radeon HD 3450
Update: AMD has officially ended its brand CrossFire for multi-GPU configurations. Now it will be called multi-GPU or mGPU and just like Nvidia, newer graphics cards from AMD will only support a 2-way multi-GPU setup. This is applicable from AMD’s latest Radeon RX Vega 64 and RX Vega 56 graphics cards.
FYI: Here is a list of all AMD Crossfire or mGPU support games: Crossfire Game Compatibility List | AMD Crossfire Wikia | Fandom
