Ever since getting my new system, I've experienced audio crackle coming from my secondary audio whenever there is some screen activity; external DAC via USB. Note: Primary audio, internal Realtek, has NOT had this issue.
I finally was able to fix it, but setting the PCI Express from gen 4 to 3 in the Bios (left the Southbridge at 4) - more accurately: I set PCIE_a to 3, PCIE_b to 2, and the PCIs to 1 (not in use anyway)
Now, I don't know if it is a MB issue, GFX card issue, or driver issue, but sound is now clean.
ASUS TUF Gaming X570 Plus
Ryzen 9 3950X
Sapphire Pulse 5700 XT