So somewhere 2 years ago AMD had a driver update that I installed which caused stuttering. I thought that it was a bug and that it would get fixed. Now, two year later, it still isn't solved. I tried deleting drivers with DDU and installing again. I tried fiddling around with a lot of settings but nothing did anything. It is a stutter every second and it's very annoying. Games start saying that I'm running unsupported drivers and I'm feeling that I can get better performance if the newer drivers worked. Instead, I have to run 17.10 drivers. Here is a video to show what happens: AMD stuttering - YouTube
MSI Z170-A motherboard
Powercolor Radeon RX 480 8GB
I had this too on my RX580 at a point where AMD also released a driver with bugged dual-monitor support.
If my 2'nd monitor (TV over HDMI) was plucked into the Graphics card, but not turned on, I'd have stuttering much like what you are showing on the vid. If I turned on the TV, stutterings were gone.
?So, are you using any type of dual monitor setup, no matter how or what is connected?
Yes, I have a small second monitor via DVI and a TV connected with HDMI (using a DisplayPort adapter). Unplugged everything except my main monitor, problem was still there. Unplugged my main monitor and plugged the TV in, still didn't solve the problem. I am going to put this GPU in a friends PC and see what it does soon. Then I'll know if it's my computer or the card.
One thing that works is installing the old drivers and then updating the drivers in device manager. But as soon as I restart my PC, the problem reoccurs.
In an attempt to identify the issue, could you please try disconnectiong your 2'nd and 3'rd monitor fron the graphics card, de-install drivers, reboot, re-install drivers, reboot and check again.
I'm just really curious to see of it has anything to do with multi-monitor again or if it's something else.
Either way, it'd be good to know what not to look for.
Edit: Oh, and reboot again if needed, to see if it comes back after another reboot like you said.