My issue is I cannot open the "AMD Radeon Settings" either from the desktop, or through "C:\Program Files\AMD\CNext\CNext\RadeonSettings.exe"
Running an RX480 on a fresh Windows 10 x64 install (fully updated). Radeon drivers updated to latest (Crimson ReLive Edition 17.11.1). Display was cloned to my TV (both displays are 1080p/60hz) with the TV getting send Limited RGB color space. I cannot give you a full rundown, as I can't access the settings.
I click to open, get the usual windows loading circle, and then nothing happens. I have already tried a complete uninstall/install via DDU and the AMD Cleanup utility. After re-installation of the drivers, the problem will go away at first, but after a few hours the settings are back to not opening.
Here is a video capture of my issue. For some reason the mouse doesn't animate, but in actuality the circle is spinning.