I've done a clean install of Windows 10, clean install of latest drivers, tried the hotfix drivers to see if condition improves.
Temperatures are great and I can game all day with no issues.
I disabled Hybrid Sleep, I disabled Sleep, I disabled Hybernation, I then even disabled monitors going to sleep and in place set a screen saver.
Every morning when I come in the machine is running with black screens, I try to wake it up but it's unresponsive (I can tell it's sort of locked up because the numlock is set to on, and if I hit the key the numlock light has no change in state)
I have two HP 24" monitors one via DVI the other also has DVI but is connected via a Display Port to DVI adapter.
Previously I had run an R9 270X on that system with zero issues for about a year or so.